Primary bone cancers include osteosarcoma , Ewing’s sarcoma, and chondrosarcoma . Osteosarcoma, the most common bone cancer, occurs most often in children and adolescents. It usually develops in the middle of the long bones, specifically the distal femur , proximal tibia, and proximal humerus.
They account for less than 1% of cancers diagnosed each year, yet it is much more common for bones to be the site of metastasis or spread from other cancers and are associated with significant morbidity and mortality.
Timely diagnosis is challenging due to late presentation of the patient, nonspecific symptoms of the malignant tumor, mimicking common musculoskeletal injuries, and low suspicion by clinicians.
Plain radiography is the preferred diagnostic test. Radiographic suspicion of bone cancer should lead to rapid referral to a cancer center for multidisciplinary care.